[HTML][HTML] Role and regulation of autophagy in cancer
R Rakesh, LC PriyaDharshini, KM Sakthivel… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
[HTML][HTML] A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: complexity and simplicity in crosstalk
Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
D Thomas, P Radhakrishnan - Molecular cancer, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …
SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal …
Y Zhu, S Huang, S Chen, J Chen, Z Wang… - Cell death & …, 2021 - nature.com
Sex-determining region Y-box2 (SOX2), a master regulator of embryonic and induced
pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and …
pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and …
[HTML][HTML] The role of osteopontin in the progression of solid organ tumour
Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment to mineralised
bone matrix, as well as being a bone matrix protein, OPN is also a versatile protein that acts …
bone matrix, as well as being a bone matrix protein, OPN is also a versatile protein that acts …
A systematic review of miR-29 in cancer
MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …
Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
SK Daniel, KM Sullivan, KP Labadie… - Clinical and translational …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to
cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor …
cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor …
Emerging role of lipid metabolism alterations in Cancer stem cells
M Yi, J Li, S Chen, J Cai, Y Ban, Q Peng, Y Zhou… - Journal of Experimental …, 2018 - Springer
Abstract Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a
small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the …
small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the …
Regulation and function of autophagy in pancreatic cancer
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …