Glial cells (astrocytes, oligodendrocytes and microglia) are critical for the central nervous
system (CNS) in both physiological and pathological conditions. With this in mind, several …

Numerous basic studies have reported on the neuroprotective properties of several purine
derivatives such as caffeine and uric acid (UA). Epidemiological studies have also shown …

Glial cells are involved in multiple cerebral functions that profoundly influence brain tissue
viability during ischemia, and astrocytes are the main source of extracellular purines as …

Astrocytes are functionally diverse glial cells that maintain blood-brain barrier (BBB)
integrity, provide metabolic and trophic support, and react to pathogens or harmful stimuli …

Severe systemic inflammation has strong effects on brain functions, promoting permanent
neurocognitive dysfunction and high mortality rates. Additionally, hippocampal damage …

Astrocytes may undergo a functional remodeling with aging, acquiring a pro-inflammatory
state. In line with this, resveratrol represents an interesting strategy for a healthier brain …

Introduction Ophiocordyceps gracilis, a type of edible and medicinal fungus, exhibits
multiple health‐promoting effects. Due to the scarcity of natural O. gracilis, artificial cultures …

With the rapid aging of the population, the control of age-related disease susceptibility and
prognosis faces greater challenges. There is an urgent need for a strategy to maintain the …

The behavior of the inclusion behavior of guanosine (GU) with beta-cyclodextrin (β-CD) in
the liquid, solid and virtual state were investigated. The absorption and fluorescence …

The nucleoside guanosine is an endogenous neuromodulator associated with
neuroprotection. The roles of guanosine during aging are still not fully elucidated …