The critical role of alpha-synuclein in Parkinson's disease represents a pivotal discovery.
Some progress has been made over recent years in identifying disease-modifying therapies …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Aims Parkinson's disease and related disorders are devastating neurodegenerative
pathologies. Since α‐synuclein was identified as a main component of Lewy bodies and …

The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of
neurodegenerative synucleinopathies, including Parkinson's disease, dementia with Lewy …

Synucleinopathies are a group of progressive neurodegenerative diseases known for the
accumulation of insoluble aggregates containing the protein alpha-synuclein (aSyn) …

Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are clinically
and neuropathologically highly related α-synucleinopathies that collectively constitute the …

Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most
abundantly found in the outer membrane of neurons. Due to structural characteristics (a …

The pathogenesis of Parkinson's disease (PD), which is a progressive neurodegenerative
disease, is associated with the formation of protein inclusion bodies called Lewy bodies (LB) …