The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …

The APOBEC family of cytidine deaminases has been proposed to represent a major
enzymatic source of mutations in cancer. Here, we summarize available evidence that links …

Although base editors are widely used to install targeted point mutations, the factors that
determine base editing outcomes are not well understood. We characterized sequence …

Mutational processes driving genome evolution and heterogeneity contribute to immune
evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes …

The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second
largest source of mutation in cancer. This mutational process may be a causal driver or …

Double-stranded RNA produced during viral replication and transcription activates both
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …

Recent studies have revealed the mutational signatures underlying the somatic evolution of
cancer, and the prevalences of associated somatic genetic variants. Here we estimate the …

Background APOBEC-driven mutagenesis and functional positive selection of mutated
genes may synergistically drive the higher frequency of some hotspot driver mutations …

The cytidine deaminases APOBEC3A (A3A) and APOBEC3B (A3B) are prominent mutators
of human cancer genomes. However, tumor-specific genetic modulators of APOBEC …

Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of
mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially …