Bottom‐up tissue engineering is a promising approach for designing modular biomimetic
structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human …

Decellularized materials (DMs) are attracting more and more attention because of their
native structures, comparatively high bioactivity, low immunogenicity and good …

Accumulating evidence suggests that the mechanical and biochemical signals originating
from cell–cell adhesion are critical for stem cell lineage specification. In this review, we focus …

Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …

Bioreactors are powerful tools with the potential to model tissue development and disease in
vitro. For nearly four decades, bioreactors have been used to create tendon and ligament …

The wide variety of cell and tissue culture systems used to study and engineer tendons can
make it difficult to choose the best approach and “optimal” culture conditions to test a given …

The problem of tendon and ligament (T/L) regeneration in musculoskeletal diseases has
long constituted a major challenge. In situ injection of formable biodegradable hydrogels …

Tendon, ligament, and skeletal muscle are highly organized tissues that largely rely on a
hierarchical collagenous matrix to withstand high tensile loads experienced in activities of …

Tendons link muscle to bone and transfer forces necessary for normal movement. Tendon
injuries can be debilitating and their intrinsic healing potential is limited. These challenges …

The treatment of injured tendon is an ever-increasing clinical and financial burden, for which
tissue-engineered replacements have shown great promise. Recently, there has been …