The ubiquitin–proteasome system (UPS) is the main regulatory mechanism of protein
degradation in skeletal muscle. The ubiquitin-ligase enzymes (E3s) have a central role in …

Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions. Its severity
reduces patient recovery, independence and quality of life. The discovery of two muscle …

We tested the hypothesis that increasing blood amino acid (AA) availability would counter
the physical inactivity‐induced reduction in muscle protein synthesis. We determined how …

Nutrition is one method to counter the negative impact of an exercise-induced injury.
Deficiencies of energy, protein and other nutrients should be avoided. Claims for the …

Sports participation is not without risk, and most athletes incur at least one injury throughout
their careers. Combat sports are popular all around the world, and about one-third of their …

Alcohol abuse, either by acute intoxication or prolonged excessive consumption, leads to
pathological changes in many organs and tissues including skeletal muscle. As muscle …

This narrative review provides mechanistic insight into the biological link between smoking
and/or chronic excess alcohol consumption, and increased risk of developing sarcopenia …

PURPOSE Alcohol-related myopathy is one of the earliest alcohol-associated pathological
tissue changes that is progressively exacerbated by cumulative long-term alcohol misuse …

Skeletal muscle mass is determined by the balance between muscle protein synthesis
(MPS) and degradation. Several intracellular signaling pathways control this balance …

The present study addressed the hypothesis that reducing mTOR, as seen in mTOR
heterozygous (+/−) mice, would exaggerate the changes in protein synthesis and …