Dementia has been increasingly more recognized to be a common feature in patients with
Parkinson's disease (PD), especially in old age. Specific criteria for the clinical diagnosis of …

Pathophysiology The establishment of a model of parkinsonism through the administration
of MPTP to nonhuman primates has provided important insights into new therapeutic …

Background Although the short-term benefits of bilateral stimulation of the subthalamic
nucleus in patients with advanced Parkinson's disease have been well documented, the …

Falls and freezing of gait are two “episodic” phenomena that are common in Parkinson's
disease. Both symptoms are often incapacitating for affected patients, as the associated …

One‐third of the 149 people recruited 15 to 18 years ago in the Sydney Multicenter Study of
Parkinson's disease have survived. The original study compared low‐dose levodopa with …

We studied prospectively the epidemiology, clinical impact and prediction of falls in 59
moderately affected patients with Parkinson's disease (PD)(mean UPDRS motor score 31.5; …

Importance Freezing of gait (FOG) is a common axial symptom of Parkinson disease (PD).
Objective To determine the prevalence of FOG in a large group of PD patients, assess its …

Deep brain stimulation of the subthalamic nucleus represents the most important innovation
for treatment of advanced Parkinson's disease. Prospective studies have shown that …

Recurrent falls are a disabling feature of Parkinson's disease (PD). We have estimated the
incidence of falling over a prospective 3 month follow‐up from a large sample size, identified …

Reviews current information on Parkinson's disease. Brain lesions; Lesions and symptoms;
Rate of degeneration of dopaminergic neurons; Death of dopaminergic neurons; Genetic …