Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …

Abstract Cyclin-dependent kinase 5 (Cdk5) is required for proper development of the
mammalian central nervous system. To be activated, Cdk5 has to associate with its …

Cell death via apoptosis is a prominent feature in mammalian neural development. Recent
studies into the basic mechanism of apoptosis have revealed biochemical pathways that …

Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number
of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Aβ …

Alzheimer's disease (AD) is the most common human neurodegenerative disorder
characterized by the progressive deterioration of cognition and memory in association with …

Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The
fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We …

Phosphatidylinositol 3‐kinase (PI3K) promotes cell survival and communication by
activating its downstream effector Akt kinase. Here we show that PS1, a protein involved in …

We report a novel gene, designated Humanin (HN) cDNA, that suppresses neuronal cell
death by K595N/M596L-APP (NL-APP), a mutant causing familial Alzheimer's disease …

Many neurological disorders involve cell death. During development of the nervous system,
cell death is a normal feature. Elimination of substantial numbers of initially generated cells …

Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS)
are the most common human adult-onset neurodegenerative diseases. They are …