Antibiotics and bacterial resistance in the 21st century

RJ Fair, Y Tor - Perspectives in medicinal chemistry, 2014 - journals.sagepub.com
Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

[HTML][HTML] Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

YT Lee, YJ Tan, CE Oon - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Cancer is the second leading cause of mortality globally which remains a continuing threat
to human health today. Drug insensitivity and resistance are critical hurdles in cancer …

Comprehensive review in current developments of benzimidazole‐based medicinal chemistry

RS Keri, A Hiremathad, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

Recent advances of imidazole-containing derivatives as anti-tubercular agents

YL Fan, XH Jin, ZP Huang, HF Yu, ZG Zeng… - European journal of …, 2018 - Elsevier
Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

Benzotriazole: An overview on its versatile biological behavior

I Briguglio, S Piras, P Corona, E Gavini… - European Journal of …, 2015 - Elsevier
Discovered in late 1960, azoles are heterocyclic compounds class which constitute the
largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical …

Tuberculosis drug discovery: A decade of hit assessment for defined targets

S Oh, L Trifonov, VD Yadav, CE Barry III… - Frontiers in Cellular …, 2021 - frontiersin.org
More than two decades have elapsed since the publication of the first genome sequence of
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …

Recent development of benzimidazole‐containing antibacterial agents

D Song, S Ma - ChemMedChem, 2016 - Wiley Online Library
Clinically significant antibiotic resistance is one of the greatest challenges of the twenty‐first
century. However, new antibacterial agents are currently being developed at a much slower …

FtsZ inhibitors as a new genera of antibacterial agents

S Tripathy, SK Sahu - Bioorganic chemistry, 2019 - Elsevier
The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial
pathogens have demanded the discovery and development of new antibacterial agents. A …

Antibacterial activity of quinoxalines, quinazolines, and 1, 5-naphthyridines

AK Parhi, Y Zhang, KW Saionz, P Pradhan… - Bioorganic & medicinal …, 2013 - Elsevier
Several phenyl substituted naphthalenes and isoquinolines have been identified as
antibacterial agents that inhibit FtsZ-Zing formation. In the present study we evaluated the …

Quantitative structure-activity relationship of molecules constituent of different essential oils with antimycobacterial activity against Mycobacterium tuberculosis and …

S Andrade-Ochoa, GV Nevárez-Moorillón… - … and alternative medicine, 2015 - Springer
Background Essential oils and their constituents are commonly known for their antibacterial,
antifungal and antiparasitic activity, and there are also reports on the antimycobacterial …