Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

With more than 4 million intensive care unit (ICU) admissions per year in the United States,
there is increasing recognition of the long-term consequences of ICU care on the physical …

Background To date, 750 000 patients with COVID-19 worldwide have required mechanical
ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We …

Background Spontaneous-breathing trials can be performed with the use of either pressure-
support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to …

BACKGROUND: Optimal timing of mechanical ventilation in COVID-19 is uncertain. We
sought to evaluate outcomes of delayed intubation and examine the ROX index (ie,[S pO 2/F …

Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management
of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design:

Background Moderate therapeutic hypothermia is currently recommended to improve
neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac …

Background There are conflicting data on the effects of antipsychotic medications on
delirium in patients in the intensive care unit (ICU). Methods In a randomized, double-blind …

Background Delirium during critical illness results from numerous insults, which might be
interconnected and yet individually contribute to long-term cognitive impairment. We sought …

Objectives: Use systematic review and meta-analytic methodology to estimate the pooled
incidence, prevalence, and proportion of delirium cases for each delirium subtype …