Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …

Astrocytes contribute to the maintenance of the health and function of the central nervous
system (CNS). Thus, it is not surprising that these multifunctional cells have been implicated …

Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …

Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …

Cholesterol is essential for neuronal physiology, both during development and in the adult
life: as a major component of cell membranes and precursor of steroid hormones, it …

Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic
neurodegenerative disorders, including Alzheimer's disease (AD), Huntington's disease …