Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

The recent introduction of biological agents has revolutionized the treatment of chronic
immune-inflammatory diseases; however, this new therapy did not come without significant …

Psoriasis is a prevalent, inflammatory skin disease without cure. Further research is required
to unravel dysregulated processes and develop new therapeutic interventions. The lack of …

Systemic immunosuppressants and biologicals have been a valuable tool in the treatment of
inflammatory diseases and malignancies. The safety profile of these drugs has been …

Psoriasis is a disease with a proinflammatory base, in which an increased expression of
leptin, tumor necrosis factor alpha (TNF-α), interleukin (IL) IL-12/23, IL-6, is observed. A drug …

ABD is a chronic multisystemic vasculitic disease with the highest prevalence in the
Mediterranean basin and in the Eastern region of Asia. Bilateral autoimmune uveitis, oral …

Die kürzlich erfolgte Einführung biologischer Wirkstoffe hat die Behandlung chronischer
immuninflammatorischer Erkrankungen revolutioniert, doch ist diese neue Therapie mit …

Background/aim: To investigate the effect of intravitreal golimumab on rabbit retina
histopathology. Materials and methods: Sixteen albino New Zealand rabbits were divided …

For the non-clinical safety evaluation of pharmaceuticals for new drug applications (NDA),
various toxicity studies must be conducted at each stage, from clinical trials to NDA. For …

Yöntem: Çalışmaya 16 adet tavşan (Yeni Zelanda albino tavşan) dahil edildi. Çalışmaya
dahil edilen tavşanlar 3 gruba ayrılarak, deneklerin sağ gözüne intravitreal Golimumab …