Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Highlights•S-adenosyl methionine-dependent methyltransferases are ubiquitous in
nature.•Analogs of S-adenosyl methionine can be produced enzymatically.•Crystallography …

High throughput genome sequencing has revealed a multitude of potential secondary
metabolites biosynthetic pathways that remain cryptic. Pathway reconstruction coupled with …

Flavin-dependent halogenases (FDHs) catalyze the halogenation of organic substrates by
coordinating reactions of reduced flavin, molecular oxygen, and chloride. Targeted and …

Malbrancheamide is a dichlorinated fungal indole alkaloid isolated from both Malbranchea
aurantiaca and Malbranchea graminicola that belongs to a family of natural products …

Alkylation of aromatic rings with alkyl halides is an important transformation in organic
synthesis, yet an enzymatic equivalent is unknown. Here, we report that cylindrocyclophane …

Isocoumarindole A (1), a novel polyketide synthetase–nonribosomal peptide synthetase
(PKS–NRPS) hybrid metabolite, was isolated from the endolichenic fungus Aspergillus sp …