[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[PDF][PDF] Mucosal immune responses to infection and vaccination in the respiratory tract

RC Mettelman, EK Allen, PG Thomas - Immunity, 2022 - cell.com
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

[HTML][HTML] Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities—workshop report

JM Knisely, LE Buyon, R Mandt, R Farkas… - npj Vaccines, 2023 - nature.com
On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases
(NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic …

[HTML][HTML] Sequential intrahost evolution and onward transmission of SARS-CoV-2 variants

AS Gonzalez-Reiche, H Alshammary… - Nature …, 2023 - nature.com
Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have
been reported in immune-compromised individuals and people undergoing immune …

[PDF][PDF] A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

B Dadonaite, KHD Crawford, CE Radford, AG Farrell… - Cell, 2023 - cell.com
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …

Fitness effects of mutations to SARS-CoV-2 proteins

JD Bloom, RA Neher - Virus Evolution, 2023 - academic.oup.com
Abstract Knowledge of the fitness effects of mutations to SARS-CoV-2 can inform
assessment of new variants, design of therapeutics resistant to escape, and understanding …

Containers for computational reproducibility

D Moreau, K Wiebels, C Boettiger - Nature Reviews Methods Primers, 2023 - nature.com
The fast-paced development of computational tools has enabled tremendous scientific
progress in recent years. However, this rapid surge of technological capability also comes at …

[HTML][HTML] The role of vaccines in the COVID-19 pandemic: what have we learned?

F Krammer - Seminars in Immunopathology, 2024 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged late in 2019 and
caused the coronavirus disease 2019 (COVID-19) pandemic that has so far claimed …

[HTML][HTML] Global landscape of SARS-CoV-2 mutations and conserved regions

MH Abbasian, M Mahmanzar, K Rahimian… - Journal of Translational …, 2023 - Springer
Background At the end of December 2019, a novel strain of Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) disease (COVID-19) has been identified in Wuhan …

Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study

B Mizrahi, T Sudry, N Flaks-Manov, Y Yehezkelli… - bmj, 2023 - bmj.com
Objectives To determine the clinical sequelae of long covid for a year after infection in
patients with mild disease and to evaluate its association with age, sex, SARS-CoV-2 …