Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

Ensuring the proper amount of water inside the body is essential for survival. One of the key
factors in the maintenance of body water balance is water reabsorption in the collecting …

Background: Phosphodiesterase 3A (PDE3A) gain-of-function mutations cause
hypertension with brachydactyly (HTNB) and lead to stroke. Increased peripheral vascular …

Background: High blood pressure is the primary risk factor for cardiovascular death
worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt …

Abstract Aquaporin‐2 (AQP2) is a member of the aquaporin water channel family. In the
kidney, AQP2 is expressed in collecting duct principal cells where it facilitates water …

Hyponatremia is frequently encountered in clinical practice and usually induced by renal
water retention. Many medications are considered to be among the various causes of …

Nephrogenic diabetes insipidus (NDI) is characterized by the inability to concentrate urine
that results in polyuria and polydipsia, despite having normal or elevated plasma …

Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal
cells through regulation of the water channel aquaporin-2 (AQP2). The hormone binds to …

Congenital nephrogenic diabetes insipidus (NDI; also known as arginine vasopressin
resistance) is a rare inherited disorder of water homeostasis, caused by insensitivity of the …

Systems biology can be defined as the study of a biological process in which all of the
relevant components are investigated together in parallel to discover the mechanism …