Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Diet-induced obesity in animal models: points to consider and influence on metabolic markers

M de Moura e Dias, SA Dos Reis… - Diabetology & Metabolic …, 2021 - Springer
Overweight and obesity are a worldwide public health problem. Obesity prevalence has
increased considerably, which indicates the need for more studies to better understand …

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis

MP LaPierre, K Lawler, S Godbersen… - Nature …, 2022 - nature.com
MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of
gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched …

[HTML][HTML] Neuronal miR-29a protects from obesity in adult mice

Y Ma, N Murgia, Y Liu, Z Li, C Sirakawin… - Molecular …, 2022 - Elsevier
Objective Obesity, a growing threat to the modern society, represents an imbalance of
metabolic queues that normally signal to the arcuate hypothalamic nucleus, a critical brain …

The expression profile and role of non-coding RNAs in obesity

S Ghafouri-Fard, M Taheri - European Journal of Pharmacology, 2021 - Elsevier
Latest years have experienced a dramatic upsurge in the knowledge about the function of
non-coding transcripts in the determination of diverse human phenotypes including obesity …

Integrating pathophysiology in migraine: Role of the gut microbiome and melatonin

G Anderson - Current pharmaceutical design, 2019 - ingentaconnect.com
Background: The pathoetiology and pathophysiology of migraine are widely accepted as
unknown. Methods: The current article reviews the wide array of data associated with the …

Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier

V Prevot, R Nogueiras, M Schwaninger - Handbook of Clinical Neurology, 2021 - Elsevier
The blood–brain barrier is generally attributed to endothelial cells. However, in
circumventricular organs, such as the median eminence, tanycytes take over the barrier …

Micromanaging the neuroendocrine system–A review on miR‐7 and the other physiologically relevant miRNAs in the hypothalamic–pituitary axis

J Zacharjasz, M Sztachera, M Smuszkiewicz… - FEBS …, 2024 - Wiley Online Library
The hypothalamic–pituitary axis is central to the functioning of the neuroendocrine system
and essential for regulating physiological and behavioral homeostasis and coordinating …

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

P Chen, Y Wang, F Chen, B Zhou - Pharmacology Research & …, 2024 - Wiley Online Library
Obesity is a major risk factor for morbidity and mortality because it has a close relationship to
metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer …

Mechanisms driving palmitate-mediated neuronal dysregulation in the hypothalamus

CV Lieu, N Loganathan, DD Belsham - Cells, 2021 - mdpi.com
The hypothalamus maintains whole-body homeostasis by integrating information from
circulating hormones, nutrients and signaling molecules. Distinct neuronal subpopulations …