Fibrinolysis is an important process in hemostasis responsible for dissolving the clot during
wound healing. Plasmin is a central enzyme in this process via its capacity to cleave fibrin …

Human C1-Inhibitor (C1INH), also known as C1-esterase inhibitor, is an important
multifunctional plasma glycoprotein that is uniquely involved in a regulatory network of …

Extracellular vesicles (EVs) participate in cell-to-cell communication and contribute toward
homeostasis under physiological conditions. But EVs can also contribute toward a wide …

Abstract Background C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with
anticoagulant activity. The impact of C1INH plasma levels within the normal physiological …

Animal models of hemostasis are often extrapolated to humans; however, only a few studies
have compared coagulation and fibrinolysis across species. Simultaneous thrombin (TG) …

The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide
challenge. The present large study sought to understand independent and overlapping …

Bipolar disorder (BD) is one of the most disabling diseases characterized by severe humor
fluctuation. It is accompanied by cognitive and functional impairment in addiction to high …

Aging and obesity independently contribute toward an endothelial dysfunction that results in
an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin …

Background Andexanet alfa is a Gla-domainless mutant (S195A) factor Xa (GDXa) approved
for acute reversal of oral factor Xa inhibitors. Cardiac surgery patients exposed to andexanet …

Aberrant coagulation in sickle cell disease (SCD) is linked to extracellular vesicle (EV)
exposure. However, there is no consensus on the contributions of small EVs (SEVs) and …