Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Many bacteria in nature exist in multicellular communities termed biofilms, where cells are
embedded in an extracellular matrix that provides rigidity to the biofilm and protects cells …

Abstract Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against
gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin …

Background Uromodulin, the most abundant protein excreted in normal urine, plays major
roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of …

Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for
visualizing biological objects, which has been driven by advances across the entire pipeline …

Assembly of extracellular filaments and matrices mediating fundamental biological
processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven …

Cell membrane‐bound serine proteases are important in the maintenance of physiological
homeostasis. Hepsin is a type II transmembrane serine protease highly expressed in the …

Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by
tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This …

Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP)
hardens and polyspermy is irreversibly blocked. These events are associated with the …