Graft versus host disease (GVHD) is a common complication and the leading cause of
morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT) …

Therapies based on injecting living cells into patients offer a huge potential to cure many
degenerative and deadly diseases, with hundreds of clinical trials ongoing. Due to their …

There is considerable interest in therapeutic transfer of regulatory T cells (Tregs) for
controlling aberrant immune responses. Initial clinical trials have shown the safety of Tregs …

BACKGROUND In preclinical murine and early clinical studies of hematopoietic cell
transplantation, engineering of donor grafts with defined ratios of CD4+ CD25+ FoxP3+ …

The blastmodulatory Kit-M, composed of granulocyte-macrophage colony-stimulating-factor
(GM-CSF) and Prostaglandin E1 (PGE 1), is known to convert myeloid leukaemic blasts …

The gut–liver axis is increasingly considered to play a vital part in the progression of chronic
inflammatory gut and liver diseases. Hence, a detailed understanding of the local and …

Regulatory T cells (Tregs) play an important role in controlling autoimmunity and limiting
tissue damage and inflammation. IL2‐inducible T cell kinase (Itk) is part of the Tec family of …

Dysregulation of the immune system undoubtedly plays an important and, perhaps,
determining role in the COVID-19 pathogenesis. While the main treatment of the COVID-19 …

Background Targeting immune checkpoints that inhibit antitumor immune responses has
emerged as a powerful new approach to treat cancer. We recently showed that blocking the …

Regulatory T (Tregs) cells play a crucial role in immunoregulation and promotion of
immunological tolerance. Adoptive transfer of these cells has therefore been of interest in …