It is well established that tissue repair depends on stem cells and that chronic wounds
predispose to tumour formation. However, the association between stem cells, wound …

BACKGROUND: Anti-oxidative extracts from the milk thistle plant (Silybum marianum) have
been shown to have antiproliferative effects in several tumor types. Silibinin is the primary …

A variety of transmembrane proteins, such as transforming growth factor‐α (TGF‐α), tumor
necrosis factor‐α (TNF‐α) and L‐selectin, undergo shedding, ie cleavage of the ectodomain …

Study of the process of cancer initiation, growth and progression in altered gravity is of
utmost importance considering the health status of researchers visiting in space and future …

Background Glioblastoma is a complex multifactorial disorder that has swift and devastating
consequences. Few genes have been consistently identified as prognostic biomarkers of …

Our hypothesis is that rotation increases apoptosis in standard tissue culture medium at
shear stresses of greater than approximately 0.3 dyn/cm 2. Human MIP-101 poorly …

Invasion of the human colonic epithelium by Shigella flexneri causes inflammation that
disrupts the intestinal barrier. Invaded intestinal epithelial cells are the major source of …

This study identifies a novel cross-talk paradigm between the type I insulin-like growth factor
receptor (IGF1R) and epidermal growth factor receptor (EGFR) in colon cancer cells. IGF1R …

The dependence of malignant properties of colorectal cancer (CRC) cells on IGF1R
signaling has been demonstrated and several IGF1R antagonists are currently in clinical …

Trefoil peptides (TFFs) are now considered as scatter factors, proinvasive and angiogenic
agents acting through cyclooxygenase-2 (COX-2)-and thromboxane A2 receptor (TXA2-R) …