Resolving the Current Controversy of Use and Reuse of Housekeeping Proteins in Ageing Research: Focus on Saving People's Tax Dollars
The use of housekeeping genes and proteins to normalize mRNA and protein levels in
biomedical research has faced growing scrutiny. Researchers encounter challenges in …
biomedical research has faced growing scrutiny. Researchers encounter challenges in …
Lower levels of tubulin alpha 1b in the frontal pole in schizophrenia supports a role for changed cytoskeletal dynamics in the aetiology of the disorder
M Snelleksz, B Dean - Psychiatry Research, 2021 - Elsevier
Our transcriptomic study suggested there were markedly lower levels of tubulin alpha 1b
(TUBA1B) expression in BA 10, but not BA 9, from patients with schizophrenia. We now use …
(TUBA1B) expression in BA 10, but not BA 9, from patients with schizophrenia. We now use …
Higher levels of AKT-interacting protein in the frontal pole from people with schizophrenia are limited to a sub-group who have a marked deficit in cortical muscarinic …
M Snelleksz, B Dean - Psychiatry Research, 2024 - Elsevier
We are studying the molecular pathology of a sub-group within schizophrenia (∼ 25%:
termed Muscarinic Receptor Deficit subgroup of Schizophrenia (MRDS)) who can be …
termed Muscarinic Receptor Deficit subgroup of Schizophrenia (MRDS)) who can be …
Lower levels of TRAF1 in Brodmann's area 24, but not 46, in bipolar disorders are not detectable in major depressive disorders
Introduction Multiple lines of research implicate inflammation-related pathways in the
molecular pathology of mood disorders, with our data suggesting a critical role for aberrant …
molecular pathology of mood disorders, with our data suggesting a critical role for aberrant …
Western blot normalization: Time to choose a proper loading control seriously
Q Wang, W Han, C Ma, T Wang, J Zhong - Electrophoresis, 2023 - Wiley Online Library
Recent research has questioned the validity of housekeeping proteins in Western blot. Our
present study proposed new ideas for Western blot normalization that improved the …
present study proposed new ideas for Western blot normalization that improved the …
Age-Specific Features of the Levels of Reference Proteins Actin, Tubulin, and GAPDH in Different Organs of Male Wistar Rats
DS Dzhalilova, AM Kosyreva, PA Vyshnyakova… - Bulletin of Experimental …, 2022 - Springer
Western blot analysis is used for evaluation of the level of proteins production in organs and
tissues, and housekeeping proteins GAPDH, actin, and tubulin are usually used as the …
tissues, and housekeeping proteins GAPDH, actin, and tubulin are usually used as the …
SMAD4 protein is decreased in the dorsolateral prefrontal and anterior cingulate cortices in schizophrenia
Objectives Signal transduction through the mothers against decapentaplegic (SMAD) is a
family of signal transduction factors that mediate signalling of the transforming growth factor …
family of signal transduction factors that mediate signalling of the transforming growth factor …
Higher levels of α7 nicotinic receptors, but not choline acetyltransferase, in the dorsolateral prefrontal cortex from a sub-group of patients with schizophrenia
B Dean, G Pavey, E Scarr - Schizophrenia Research, 2020 - Elsevier
It has been suggested the study of sub-groups within the syndrome of schizophrenia will
assist in elucidating the complex pathophysiology of the syndrome. Hence, we have studied …
assist in elucidating the complex pathophysiology of the syndrome. Hence, we have studied …
Cortical expression of the RAPGEF1 gene in schizophrenia: investigating regional differences and suicide
Rap guanine nucleotide exchange factor 1 (RAPGEF1) is involved in cell adhesion and
neuronal migration. Previously we found lower RAPGEF1 mRNA levels in Brodmann's area …
neuronal migration. Previously we found lower RAPGEF1 mRNA levels in Brodmann's area …
Возрастные особенности уровня референсных белков-актина, тубулина и GAPDH в разных органах у самцов крыс Вистар
ДШ Джалилова, АМ Косырева, ПА Вишнякова… - … Biologii i Meditsiny, 2022 - elibrary.ru
Для оценки уровня продукции белков в органах и тканях используется метод вестерн-
блот анализа, в качестве референсных белков, как правило, выступают белки" …
блот анализа, в качестве референсных белков, как правило, выступают белки" …