Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Adnexal tumors of the skin are a rare group of benign and malignant neoplasms that exhibit
morphological differentiation toward one or more of the adnexal epithelium types present in …

Poroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The
present study aimed to explore the potential role of gene fusions in the tumorigenesis of …

Poroma is a benign sweat gland tumour showing morphological features recapitulating the
superficial portion of the eccrine sweat coil. A subset of poromas may transform into …

Structural alterations of NUTM1 were originally thought to be restricted to poorly
differentiated carcinomas with variable squamous differentiation originating in the midline …

Simple Summary Cutaneous sweat gland tumors form an extremely diverse and
heterogeneous group of neoplasms that show histological differentiation to the sweat …

Simple Summary Porocarcinoma (PC) is very rare and is known to arise from the cutaneous
intraepidermal ducts of the sweat glands. Diagnosing PC used to be challenging due to the …

Background Adnexal skin tumors are diagnostically challenging with few known molecular
signatures. Recently, however, YAP1‐MAML2 and YAP1‐NUTM1 fusions were identified in …

Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at
many anatomic sites, the driving molecular alterations underlying their progression from …

Eccrine porocarcinoma (EPC) constitutes a rare malignant adnexal tumor, which accounts
for about 0.005–0.01% of all cutaneous malignancies. It may develop de novo or arise from …