Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

Celastrol, triptolide and triptonide are the most significant active ingredients of Tripterygium
wilfordii Hook F (TWHF). In 2007, the 'Cell'journal ranked celastrol, triptolide, artemisinin …

Type 2 diabetic osteoporosis (T2DOP) is a chronic bone metabolic disease. Compared with
traditional menopausal osteoporosis, the long-term high glucose (HG) microenvironment …

Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

The skeletal muscle (SkM) is the largest organ, which plays a vital role in controlling
musculature, locomotion, body heat regulation, physical strength, and metabolism of the …

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver
diseases worldwide, and its prevalence is still growing rapidly. However, the efficient …

Cardiovascular diseases (CVD) are leading causes of morbidity and mortality worldwide;
therefore, seeking effective therapeutics to reduce the global burden of CVD has become …

Obesity is characterized by an adipose tissue mass expansion that presents a risk to health,
associated with a chronic increase in circulating inflammatory mediators. Anti-inflammatory …

Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …

Background Diabetic wounds represent a severe clinical challenge in which impaired M2
macrophage polarization and continuous macrophage glycolysis play crucial roles …