Bile salt hydrolase activity in probiotics
Probiotics are defined as “living microorganisms, which upon ingestion in certain numbers
exert health benefits on the host beyond inherent basic nutrition”(43). Various studies have …
exert health benefits on the host beyond inherent basic nutrition”(43). Various studies have …
Biodegradation of Aromatic Compounds byEscherichia coli
Although Escherichia coli has long been recognized as the best-understood living organism,
little was known about its abilities to use aromatic compounds as sole carbon and energy …
little was known about its abilities to use aromatic compounds as sole carbon and energy …
Functional Analysis of Four Bile Salt Hydrolase and Penicillin Acylase Family Members in Lactobacillus plantarum WCFS1
JM Lambert, RS Bongers, WM de Vos, M Kleerebezem - 2008 - Am Soc Microbiol
Bile salts play an important role in the digestion of lipids in vertebrates and are synthesized
and conjugated to either glycine or taurine in the liver. Following secretion of bile salts into …
and conjugated to either glycine or taurine in the liver. Following secretion of bile salts into …
Immobilization of penicillin G acylase: the key to optimum performance
AI Kallenberg, F van Rantwijk… - Advanced Synthesis & …, 2005 - Wiley Online Library
Penicillin G acylase is a major industrial biocatalyst that is used in the enzymatic production
of 20,000 ta− 1 of 6‐aminopenicillanic acid, the industrial β‐lactam intermediate, as well as …
of 20,000 ta− 1 of 6‐aminopenicillanic acid, the industrial β‐lactam intermediate, as well as …
Biotechnological applications of penicillin acylases: state-of-the-art
M Arroyo, I De la Mata, C Acebal… - Applied microbiology and …, 2003 - Springer
This review describes the most recent developments in the biotechnological applications of
penicillin acylases. This group of enzymes is involved mainly in the industrial production of 6 …
penicillin acylases. This group of enzymes is involved mainly in the industrial production of 6 …
Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism
The crystal structure of penicillin G acylase from Escherichia coli has been determined to a
resolution of 1.3 Å from a crystal form grown in the presence of ethylene glycol. To study …
resolution of 1.3 Å from a crystal form grown in the presence of ethylene glycol. To study …
Application of biocatalysis and biotransformations to the synthesis of pharmaceuticals
A Zaks, DR Dodds - Drug Discovery Today, 1997 - Elsevier
The application of biologically derived catalysts to the synthesis of pharmaceuticals has
grown rapidly in recent years. This review covers examples of isolated enzymes and …
grown rapidly in recent years. This review covers examples of isolated enzymes and …
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster
We have determined and analyzed the nucleic acid sequence of a 14,855-bp region that
contains the complete gene cluster encoding the 4-hydroxyphenylacetic acid (4-HPA) …
contains the complete gene cluster encoding the 4-hydroxyphenylacetic acid (4-HPA) …
Shared strategies for β-lactam catabolism in the soil microbiome
The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them.
While resistance genes are widely distributed in the soil, there is a dearth of knowledge …
While resistance genes are widely distributed in the soil, there is a dearth of knowledge …
Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active-site cleft
L Hewitt, V Kasche, K Lummer, RJ Lewis… - Journal of molecular …, 2000 - Elsevier
Penicillin G acylase is a periplasmic protein, cytoplasmically expressed as a precursor
polypeptide comprising a signal sequence, the A and B chains of the mature enzyme (209 …
polypeptide comprising a signal sequence, the A and B chains of the mature enzyme (209 …