For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …

Background Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor
mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like …

MATERIALS AND METHODS Surgical preparation. The experimental animals were handled
in compliance with the Guiding Principles in the Use and Care of Animals published by the …

Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and
constitutes a major source of cognitive decline in the elderly. SVD is known to occur in …

Background—Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes
infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular and …

The importance of reactive oxygen species (ROS) in vascular physiology and pathology is
becoming increasingly evident. All cell types in the vascular wall produce ROS derived from …

Acute lung injury (ALI) and its most severe form, the acute respiratory distress syndrome
(ARDS) are frequent complications in critically ill patients and are responsible for significant …

Activation of vascular NAD (P) H oxidases and the production of reactive oxygen species
(ROS) by these enzyme systems are common in cardiovascular disease. In the past several …

Endothelial dysfunction comprises a number of functional alterations in the vascular
endothelium that are associated with diabetes and cardiovascular disease, including …