Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography

H Komatsu, G Onoguchi, SM Silverstein, S Jerotic… - Molecular …, 2024 - nature.com
Introduction Abnormal findings on optical coherence tomography (OCT) and
electroretinography (ERG) have been reported in participants with schizophrenia spectrum …

Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies

PA Constable, JKH Lim, DA Thompson - Frontiers in Neuroscience, 2023 - frontiersin.org
The retina and brain share similar neurochemistry and neurodevelopmental origins, with the
retina, often viewed as a “window to the brain.” With retinal measures of structure and …

Eye-brain connections revealed by multimodal retinal and brain imaging genetics

B Zhao, Y Li, Z Fan, Z Wu, J Shu, X Yang… - Nature …, 2024 - nature.com
The retina, an anatomical extension of the brain, forms physiological connections with the
visual cortex of the brain. Although retinal structures offer a unique opportunity to assess …

[HTML][HTML] Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

B Zhao, Y Li, Z Fan, Z Wu, J Shu, X Yang, Y Yang… - medRxiv, 2023 - ncbi.nlm.nih.gov
As an anatomical extension of the brain, the retina of the eye is synaptically connected to the
visual cortex, establishing physiological connections between the eye and the brain. Despite …

Precision psychiatry and Research Domain Criteria: Implications for clinical trials and future practice

LM Williams, WT Carpenter, C Carretta… - CNS …, 2024 - cambridge.org
Psychiatric disorders are associated with significant social and economic burdens, many of
which are related to issues with current diagnosis and treatments. The coronavirus (COVID …

Detecting accelerated retinal decline in mental disorders through normative modeling

F Georgiadis, N Kallen, G Cecere, F Rabe, V Edkins… - medRxiv, 2024 - medrxiv.org
Objective Several studies have found thinner retinal tissue in mental disorders compared to
healthy controls. Because the retina is part of the human brain, this suggests that informative …

[HTML][HTML] Association between visual impairment and psychosis: A longitudinal study and nested case-control study of adults

N Shoham, G Lewis, JF Hayes, SM Silverstein… - Schizophrenia …, 2023 - Elsevier
Background Theories propose that visual impairment might increase the risk of psychosis,
and vice versa. We aimed to investigate the relationship between visual impairment and …

[HTML][HTML] Genetic polymorphism and neuroanatomical changes in schizophrenia

MG Năstase, I Vlaicu, SC Trifu - Romanian Journal of Morphology …, 2022 - ncbi.nlm.nih.gov
The article is a review of the latest meta-analyses regarding the genetic spectrum in
schizophrenia, discussing the risks given by the disrupted-in-schizophrenia 1 (DISC1) …

[HTML][HTML] High-density retinal signal deciphering in support of diagnosis in psychiatric disorders: A new paradigm

S Massoda, H Rakkay, C Émond, V Tellier… - … Signal Processing and …, 2025 - Elsevier
Background The search for biomarkers in psychiatry started decades ago with major
reported milestones in the development of computational psychiatry and precision medicine …

[HTML][HTML] Retinal structure and its relationship with premorbid, clinical, and cognitive variables in young Spanish patients with early course schizophrenia spectrum …

JM González-Díaz, BS Dalmau… - European …, 2025 - Elsevier
Emerging evidence suggests that retinal structural alterations are present in schizophrenia
spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and …