Biomedical research and clinical practice are struggling to cope with the growing complexity
that the progress of health care involves. The most challenging diseases, those with the …

A wide variety of bone diseases have hitherto been discovered, such as osteoporosis,
Paget's disease, osteopetrosis, and metastatic bone disease, which are not well defined in …

While bone tissue is a hierarchically organized material, mathematical formulations of bone
remodeling are often defined on the level of a millimeter-sized representative volume …

Osteoporosis disrupts the healthy remodelling process in bone and affects its mechanical
properties. Mechanical loading has been shown to be effective in stimulating bone formation …

Understanding bone mechanics at different hierarchical levels is fundamental to improve
preclinical and clinical assessments of bone strength. Digital Volume Correlation (DVC) is …

Bone remodeling is a fundamental biological process that develops in bone tissue along its
whole lifetime. It refers to a continuous bone transformation with new bone formation and old …

The two major aims of the present study were:(i) quantify localised cortical bone adaptation
at the surface level using contralateral endpoint imaging data and image analysis …

Highlights•Choice of modeling framework should account for experimental context and
data.•Accurate models offer biological insight and explain non-intuitive observations.•Multi …

Abstract Purpose of Review We review the literature on hip fracture mechanics and models
of hip strain during exercise to postulate the exercise regimen for best promoting hip …

The main motivation for “hierarchical biomechanics” is that the wide variability of mechanical
properties encountered at the macroscopic scale may be traced back to just a few …