Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Peptidylarginine deiminases (PADs) transform a protein arginine residue into the non-
standard amino acid citrulline. This calcium-dependent post-translational modification of …

Autophagy is a highly conserved process from yeast to mammals in which intracellular
materials are engulfed by a double-membrane organelle called autophagosome and …

Abstract Transglutaminase 1 (TGM1) plays an essential role in skin barrier formation by
cross-linking proteins in differentiated keratinocytes. Here, we established a protocol for the …

Deimination, also known as citrullination, corresponds to the conversion of the amino acid
arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post …

Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-
dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is …

The epidermal barrier refers to the stratum corneum, the uppermost layer of the skin, and
constitutes the first line of defense against invasion by potentially harmful pathogens …

Desmosomes are cadherin-based adhesion structures that mechanically couple the
intermediate filament cytoskeleton of adjacent cells to confer mechanical stress resistance to …

The ZDHHC13/ZDHHC17 subfamily belongs to the zinc finger DHHC-domain containing
(ZDHHC) family, including ZDHHC13 and ZDHHC17. Recent studies have shown that the …

Mannosylerythritol lipids (MELs) may prevent skin barrier damage, although their protective
mechanisms and active monomeric constituents remain unclear. Here, three MELs were …