Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities
of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell …

Cancer is widely considered to be a set of genetic diseases that are currently classified by
tissue and cell type of origin and, increasingly, by its molecular characteristics. This latter …

Sin3 is an evolutionarily conserved repressor protein complex mainly associated with
histone deacetylase (HDAC) activity. Many proteins are part of Sin3/HDAC complexes, and …

Pleiotropically acting eukaryotic corepressors such as retinoblastoma and SIN3 have been
found to physically interact with many widely expressed “housekeeping” genes. Evidence …

Cu+‐chaperones are a diverse group of proteins that allocate Cu+ ions to specific copper
proteins, creating different copper pools targeted to specific physiological processes …

The chromatin environment has a significant impact on gene expression. Chromatin
structure is highly regulated by histone modifications and RNA polymerase II binding …

Swi-independent 3a and 3b (Sin3a and Sin3b) are paralogous transcriptional coregulators
that direct cellular differentiation, survival, and function. Here, we report that mouse Sin3a …

Transcriptional regulation in eukaryotic cells involves the activity of multifarious DNA-binding
transcription factors and recruited corepressor complexes. Together, these complexes …

To survive in the tumour microenvironment, cancer cells undergo rapid metabolic
reprograming and adaptability. One of the key characteristics of cancer is increased …

The SIN3 scaffolding protein is a conserved transcriptional regulator known to fine-tune
gene expression. In Drosophila, there are two major isoforms of SIN3, SIN3 220 and SIN3 …