Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

This review focuses on the remodeling of brain circuitry associated with epilepsy, particularly
in excitatory glutamate and inhibitory GABA systems, including alterations in synaptic …

The hippocampal dentate gyrus is often viewed as a segregator of upstream information.
Physiological support for such function has been hampered by a lack of well-defined …

The circuitry of the dentate gyrus (DG) of the hippocampus is unique compared to other
hippocampal subfields because there are two glutamatergic principal cells instead of one …

The hippocampus is typically described in the context of the trisynaptic circuit, a pathway that
relays information from the perforant path to the dentate gyrus, dentate to area CA3, and …

Recent evidences suggest key roles of abnormal neurogenesis and astrogliosis in the
pathogenesis of epilepsy. Alterations in the microenvironment of the stem cell, such as …

To test the hypothesis that induction of BDNF may contribute to changes in hippocampal
excitability occurring during the female reproductive cycle, we examined the distribution of …

Mossy cell loss and mossy fiber sprouting are two characteristic consequences of repeated
seizures and head trauma. However, their precise contributions to the hyperexcitable state …

The “dormant basket cell” hypothesis suggests that postinjury hippocampal network
hyperexcitability results from the loss of vulnerable neurons that normally excite insult …

Accumulation of abnormally integrated, adult-born, hippocampal dentate granule cells
(DGCs) is hypothesized to contribute to the development of temporal lobe epilepsy (TLE) …