Endocannabinoids are readily accumulated from the extracellular space by cells. Although
their uptake properties have the appearance of a process of facilitated diffusion, it is by no …

The endocannabinoids anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl
glycerol (2AG) are physiologically occurring, biologically active compounds on CB1 and …

N-Acylethanolamines (NAEs) are bioactive lipids that engage diverse receptor systems.
Recently, we identified fatty acid-binding proteins (FABPs) as intracellular NAE carriers …

Opportunities for developing innovative and intelligent drug delivery technologies by
targeting the endocannabinoid system are becoming more apparent. This review provides …

In this review, we present our understanding of the action and metabolism of
endocannabinoids and related endogenous molecules. It is clear that the interactions …

Pain is one of the most significant causes of suffering and disability world-wide, and
arguably the most burdensome global health challenge. The growing number of patients …

The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from
the extracellular space by a process of cellular uptake followed by metabolism. Although the …

Introduction Rodent models are routinely used to assess the safety and developmental
toxicity of pharmaceuticals, along with analysis of their distribution. These models require …

Although cannabis has been used both recreationally and for medicinal purposes since
ancient times, it was not until the 1990s that the receptors responsible for many of the …

Background and purpose: Genistein, a tyrosine kinase inhibitor used to block caveolae
dependent endocytosis, reduces the cellular uptake of anandamide in RBL2H3 basophilic …