Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders

Y Li, W Zhi, B Qi, L Wang, X Hu - Frontiers in Behavioral …, 2023 - frontiersin.org
Fear refers to an adaptive response in the face of danger, and the formed fear memory acts
as a warning when the individual faces a dangerous situation again, which is of great …

Multiverse analyses in fear conditioning research

TB Lonsdorf, A Gerlicher, M Klingelhöfer-Jens… - … Research and Therapy, 2022 - Elsevier
There is heterogeneity in and a lack of consensus on the preferred statistical analyses in
light of a multitude of potentially equally justifiable approaches. Here, we introduce …

Robust group-but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

M Klingelhöfer-Jens, MR Ehlers, M Kuhn, V Keyaniyan… - Elife, 2022 - elifesciences.org
Here, we follow the call to target measurement reliability as a key prerequisite for individual-
level predictions in translational neuroscience by investigating (1) longitudinal reliability at …

[HTML][HTML] The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD

KM Crombie, AA Privratsky, CM Schomaker… - NeuroImage: Clinical, 2022 - Elsevier
Abstract Background Posttraumatic Stress Disorder (PTSD) is commonly treated with
exposure-based cognitive therapies that are based on the principles of fear acquisition and …

Morphologic alterations of the fear circuitry: the role of sex hormones and oral contraceptives

A Brouillard, LM Davignon, AM Turcotte… - Frontiers in …, 2023 - frontiersin.org
Background Endogenous sex hormones and oral contraceptives (OCs) have been shown to
influence key regions implicated in fear processing. While OC use has been found to impact …

Fear-potentiated startle reveals diminished threat extinction in pathological anxiety

P Newsome, SG Ruiz, AL Gold, DS Pine… - International Journal of …, 2023 - Elsevier
Background Major theories propose that perturbed threat learning is central to pathological
anxiety, but empirical support is inconsistent. Failures to detect associations with anxiety …

Acute anxiety during the COVID-19 pandemic was associated with higher levels of everyday altruism

JB Vieira, S Pierzchajlo, S Jangard, AA Marsh… - Scientific Reports, 2022 - nature.com
Prior laboratory research has suggested that humans may become more prosocial in
stressful or threatening situations, but it is unknown whether the link between prosociality …

Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults

M Klingelhöfer-Jens, K Hutterer, MA Schiele, EJ Leehr… - bioRxiv, 2023 - biorxiv.org
Childhood adversity is a strong predictor for developing psychopathological conditions.
Exposure to threat-related childhood adversity has been suggested to be specifically linked …

The robustness of fear: Challenges of methodological heterogeneity in fear conditioning research

M Klingelhöfer-Jens - 2023 - ediss.sub.uni-hamburg.de
Meta-science or meta-research is the study of science's own methods and practices in order
to improve research practices and ensure the integrity of scientific processes. Three key …

Acute anxiety during the COVID-19 pandemic was associated with higher levels of everyday altruism

JB Vieira, S Pierzchajlo, S Jangard, A Marsh, A Olsson - 2020 - osf.io
Threatening situations have been shown to influence prosocial and altruistic behaviour in
laboratory studies. However, it is unknown whether those effects would transfer to a real-life …