[HTML][HTML] TGF-β in developmental and fibrogenic EMTs

JH Lee, J Massagué - Seminars in cancer biology, 2022 - Elsevier
TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs)
during development and wound healing and in disease conditions such as fibrosis and …

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

EMT in cancer

T Brabletz, R Kalluri, MA Nieto, RA Weinberg - Nature Reviews Cancer, 2018 - nature.com
Similar to embryonic development, changes in cell phenotypes defined as an epithelial to
mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process …

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Y Zhang, RA Weinberg - Frontiers of medicine, 2018 - Springer
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an
important role in both development and cancer progression. Depending on the contextual …

Context-dependent EMT programs in cancer metastasis

NM Aiello, Y Kang - Journal of Experimental Medicine, 2019 - rupress.org
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …

Emerging role of tumor cell plasticity in modifying therapeutic response

S Qin, J Jiang, Y Lu, EC Nice, C Huang… - Signal transduction and …, 2020 - nature.com
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Epithelial–mesenchymal transition in tumor metastasis

KT Yeung, J Yang - Molecular oncology, 2017 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) is a developmental program that enables
stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells …

EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?

A Akhmetkaliyev, N Alibrahim, D Shafiee, E Tulchinsky - Molecular Cancer, 2023 - Springer
Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are
genetic determinants of cellular plasticity. These programs operate in physiological …

Mesenchymal–epithelial transition in development and reprogramming

D Pei, X Shu, A Gassama-Diagne, JP Thiery - Nature cell biology, 2019 - nature.com
During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–
mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can …

Regulatory networks defining EMT during cancer initiation and progression

BD Craene, G Berx - Nature Reviews Cancer, 2013 - nature.com
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …