Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription
ME Wilkinson, CJ Frangieh, RK Macrae, F Zhang - Science, 2023 - science.org
Non–long terminal repeat (non-LTR) retrotransposons, or long interspersed nuclear
elements (LINEs), are an abundant class of eukaryotic transposons that insert into genomes …
elements (LINEs), are an abundant class of eukaryotic transposons that insert into genomes …
Structures, functions and adaptations of the human LINE-1 ORF2 protein
ET Baldwin, T van Eeuwen, D Hoyos, A Zalevsky… - Nature, 2024 - nature.com
Abstract The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
Template and target-site recognition by human LINE-1 in retrotransposition
The long interspersed element-1 (LINE-1, hereafter L1) retrotransposon has generated
nearly one-third of the human genome and serves as an active source of genetic diversity …
nearly one-third of the human genome and serves as an active source of genetic diversity …
L1-ORF1p nucleoprotein can rapidly assume distinct conformations and simultaneously bind more than one nucleic acid
Abstract LINE-1 (L1) is a parasitic retrotransposable DNA element, active in primates for the
last 80–120 Myr. L1 has generated nearly one-third of the human genome by copying its …
last 80–120 Myr. L1 has generated nearly one-third of the human genome by copying its …
[HTML][HTML] Domain Mobility in the ORF2p Complex Revealed by Molecular Dynamics Simulations and Big Data Analysis
AM Kulakova, MG Khrenova, MI Zvereva… - International Journal of …, 2024 - mdpi.com
ORF2p (open reading frame 2 protein) is a multifunctional multidomain enzyme that
demonstrates both reverse transcriptase and endonuclease activities and is associated with …
demonstrates both reverse transcriptase and endonuclease activities and is associated with …
Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
AM D'Ordine, G Jogl, JM Sedivy - Nature Communications, 2024 - nature.com
The long interspersed nuclear element-1 (LINE-1 or L1) retrotransposon is the only active
autonomously replicating retrotransposon in the human genome. L1 harms the cell by …
autonomously replicating retrotransposon in the human genome. L1 harms the cell by …
Characterizing Multi-Modal Interactions of Single-Stranded Nucleic Acid Binding Proteins From T4 Bacteriophage and the LINE-1 Retrotransposon
BA Cashen - 2024 - search.proquest.com
Single molecule force spectroscopy is a powerful tool for characterizing protein-DNA
interactions. DNA stretching in optical tweezers provides high resolution measurements of …
interactions. DNA stretching in optical tweezers provides high resolution measurements of …