The cyclin-dependent kinase (Cdk) inhibitor p27 (also known as KIP1) regulates cell
proliferation, cell motility and apoptosis. Interestingly, the protein can exert both positive and …

As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing
cancer therapeutic target. Recent studies have investigated the mechanisms underlying the …

We have shown a novel mechanism of Akt-mediated regulation of the CDK inhibitor
p27kip1. Blockade of HER2/neu in tumor cells inhibits Akt kinase activity and upregulates …

The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …

The cyclin-dependent kinase inhibitor p27kip1 is a putative tumor suppressor for human
cancer. The mechanism underlying p27kip1 deregulation in human cancer is, however …

p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family.
p27 expression is regulated by cell contact inhibition and by specific growth factors, such as …

Abstract p27 is a cell cycle inhibitor whose cellular abundance increases in response to
many antimitogenic stimuli. In this review, we summarize the current knowledge on p27 …

Abstract p27 acts as a critical negative regulator of the cell cycle by inhibiting the activity of
cyclin/cdk complexes during G0 and G1. Degradation of p27 is a critical event for the G1/S …

The multistage process of carcinogenesis involves the progressive acquisition of mutations,
and epigenetic abnormalities in the expression, of multiple genes that have highly diverse …

A major function of p27, also known as Kip1, is to bind and inhibit cyclin/cyclin-dependent
kinase complexes, thereby blocking cell cycle progression. As p27 operates at the heart of …