The pattern of delayed recurrence in a subset of breast cancer patients has long been
explained by a model that incorporates a variable period of cellular or tumor mass dormancy …

The survival and recurrence of dormant tumour cells following therapy is a leading cause of
death in patients with cancer. The metabolic properties of these cells are likely to be distinct …

Background Obesity is associated with an increased risk of breast cancer recurrence and
cancer death. Recurrent cancers arise from the pool of residual tumor cells, or minimal …

Ubiquitin (Ub) and ubiquitin-like (Ubl) pathways are critical post-translational modifications
that determine whether functional proteins are degraded or activated/inactivated. To date,> …

The survival and recurrence of residual tumor cells following therapy constitutes one of the
biggest obstacles to obtaining cures in breast cancer, but it remains unclear how the clonal …

Extracellular signals have been shown to impact on alternative pre-mRNA splicing;
however, the molecular mechanisms and biological significance of signal-induced splicing …

Melanoma is one of the most common skin malignancies. Both microRNAs and long non-
coding RNAs (lncRNAs) have critical roles in the progression of cancers, including …

Introduction Breast cancer survivors face dual challenges: long term sequelae of treatment,
and risk of recurrent disease. Obesity and a sedentary lifestyle complicate both challenges …

Background Breast cancer mortality is principally due to recurrent disease that becomes
resistant to therapy. We recently identified copy number (CN) gain of the putative membrane …

Breast cancer recurrence is the greatest contributor to patient death. As the immune system
has a long-term immune memory effect, immunotherapy has great potential for preventing …