The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Posttranscriptional modifications of transfer RNAs (tRNAs) are critical for all core aspects of
tRNA function, such as folding, stability, and decoding. Most tRNA modifications were …

The function of RNA is subtly modulated by post-transcriptional modifications. Here, we
report an important crosstalk in the covalent modification of two classes of RNAs. We …

Protein translation is an energetically demanding process that must be regulated in
response to changes in nutrient availability. Herein, we report that intracellular methionine …

Transfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis
employs a specialized RNA polymerase that generates initial transcripts that must be …

Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of
translation in all organisms. The anticodon modification mcm5s2U34 is required for normal …

Covalent nucleotide modifications in noncoding RNAs affect a plethora of biological
processes, and new functions continue to be discovered even for well-known modifying …

Both, DNA and RNA nucleoside modifications contribute to the complex multi-level
regulation of gene expression. Modified bases in tRNAs modulate protein translation rates in …

Wobble uridines (U34) are generally modified in all species. U34 modifications can be
essential in metazoans but are not required for viability in fungi. In this review, we provide an …

The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as
an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display …