The intrinsic deficiencies of nanoparticle‐initiated catalysis for biomedical applications
promote the fast development of alternative versatile theranostic modalities. The catalytic …

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …

The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …

INTRODUCTION DNA methylation is essential to mammalian development, and
dysregulation can cause serious pathological conditions, including immunodeficiency …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …

Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

Electrical stimulation holds promise for enhancing neuronal differentiation of neural stem
cells to treat traumatic brain injury. However, once the stem cells leave the stimulating …