Type VII secretion systems: structure, functions and transport models

A Rivera-Calzada, N Famelis, O Llorca… - Nature Reviews …, 2021 - nature.com
Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

ESX-3 secretion system in Mycobacterium: An overview

AL Granados-Tristán, CE Hernández-Luna… - Biochimie, 2023 - Elsevier
Mycobacteria are microorganisms distributed in the environment worldwide, and some of
them, such as Mycobacterium tuberculosis or M. leprae, are pathogenic. The hydrophobic …

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence

MM Osman, JK Shanahan, F Chu… - Proceedings of the …, 2022 - National Acad Sciences
Mycobacterium tuberculosis and its close relative Mycobacterium marinum infect
macrophages and induce the formation of granulomas, organized macrophage-rich immune …

The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in Mycobacterium tuberculosis

A Gijsbers, M Eymery, Y Gao, I Menart… - Journal of Biological …, 2023 - ASBMB
Pathogenic species from the Mycobacterium genus are responsible for a number of adverse
health conditions in humans and animals that threaten health security and the economy …

Mycobacterial type VII secretion systems

N Famelis, S Geibel, D van Tol - Biological Chemistry, 2023 - degruyter.com
Mycobacteria, such as the pathogen M. tuberculosis, utilize up to five paralogous type VII
secretion systems to transport proteins across their cell envelope. Since these proteins …

Interaction of zincite, alpha-terpineol, geranyl acetate, linalool, myrcenol, terpinolene, and thymol with virulence factors of Escherichia coli, Mycobacterium tuberculosis …

M Alavi, M Ashengroph - Expert Review of Anti-infective Therapy, 2024 - Taylor & Francis
Background Based on gas chromatography–mass spectrometry (GC-MS) results of a
previous study, six metabolites including alpha-terpineol, geranyl acetate, linalool, myrcenol …

Cryo-EM reveals the membrane-binding phenomenon of EspB, a virulence factor of the mycobacterial type VII secretion system

N Sengupta, S Padmanaban, S Dutta - Journal of Biological Chemistry, 2023 - ASBMB
Mycobacterium tuberculosis (Mtb) utilizes sophisticated machinery called the type VII
secretion system to translocate virulence factors across its complex lipid membrane. EspB …

Interaction of Carbon Nanotubes, Capped Carbon Nanotubes, CNT2–5, C60, C70, HO-C60, [C60]2, and [C60]3 Fullerenes with Virulence Factors of Gram …

M Alavi, M Ashengroph, MR Mozafari - Inorganics, 2024 - mdpi.com
The antimicrobial application of carbon nanomaterials, such as carbon nanotubes (CNTs),
capped CNTs, CNT2–5, C60, C70, HO-C60,[C60] 2, and [C60] 3 fullerenes, is increasing …

Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates

C Toniolo, N Dhar, JD McKinney - The EMBO Journal, 2023 - embopress.org
Mycobacterium tuberculosis (Mtb) infection is initiated by inhalation of bacteria into lung
alveoli, where they are phagocytosed by resident macrophages. Intracellular Mtb replication …

Mycobacterium tuberculosis EspK has active but distinct roles in the secretion of EsxA and EspB

ZL Lim, K Drever, N Dhar, ST Cole… - Journal of …, 2022 - Am Soc Microbiol
The Mycobacterium tuberculosis type-7 protein secretion system ESX-1 is a major driver of
its virulence. While the functions of most ESX-1 components are characterized, many others …