Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Mycobacterium species, including the human pathogen Mycobacterium tuberculosis, are
unique among Gram-positive bacteria in producing a complex cell wall that contains …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

The re-emergence of tuberculosis in its present-day manifestations–single, multiple and
extensive drug-resistant forms and as HIV-TB coinfections–has resulted in renewed …

Humans have been increasingly recognized as being superorganisms, living in close
contact with a microbiota on all their mucosal surfaces. However, most studies on the human …

Several human pathogens are to be found within the bacterial genus Mycobacterium,
notably Mycobacterium tuberculosis, the causative agent of tuberculosis, one of the most …

Lipomannan (LM) and lipoarabinomannan (LAM) are mycobacterial glycolipids containing a
long mannose polymer. While they are implicated in immune modulations, the significance …

Glycosylphosphatidylinositol (GPI) is a glycolipid that is covalently attached to proteins as a
post-translational modification. Such modification leads to the anchoring of the protein to the …

Phosphatidylinositol mannosides (PIMs) are a major class of glycolipids in all mycobacteria.
AcPIM2, a dimannosyl PIM, is both an end product and a precursor for polar PIMs, such as …