Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects
M Hoogenboom, D Eikelenboom, MH den Brok… - Ultrasound in medicine …, 2015 - Elsevier
The best known method of high-intensity focused ultrasound is thermal ablation, but interest
in non-thermal, mechanical destruction is increasing. The advantages of mechanical …
in non-thermal, mechanical destruction is increasing. The advantages of mechanical …
MR thermometry during transcranial MR imaging–guided focused ultrasound procedures: a review
Interest in transcranial MR imaging–guided focused ultrasound procedures has recently
grown. These incisionless procedures enable precise focal ablation of brain tissue using …
grown. These incisionless procedures enable precise focal ablation of brain tissue using …
Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound
N Hijnen, E Kneepkens, M de Smet… - Proceedings of the …, 2017 - National Acad Sciences
Several thermal-therapy strategies such as thermal ablation, hyperthermia-triggered drug
delivery from temperature-sensitive liposomes (TSLs), and combinations of the above were …
delivery from temperature-sensitive liposomes (TSLs), and combinations of the above were …
MRI methods for the evaluation of high intensity focused ultrasound tumor treatment: Current status and future needs
SJCG Hectors, I Jacobs, CTW Moonen… - Magnetic resonance …, 2016 - Wiley Online Library
Thermal ablation with high intensity focused ultrasound (HIFU) is an emerging noninvasive
technique for the treatment of solid tumors. HIFU treatment of malignant tumors requires …
technique for the treatment of solid tumors. HIFU treatment of malignant tumors requires …
In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology
M Hoogenboom, D Eikelenboom… - NMR in …, 2016 - Wiley Online Library
Boiling histotripsy (BH) is a new high intensity focused ultrasound (HIFU) ablation technique
to mechanically fragmentize soft tissue into submicrometer fragments. So far, ultrasound has …
to mechanically fragmentize soft tissue into submicrometer fragments. So far, ultrasound has …
Gradually evaluating of suicidal risk in depression by semi-supervised cluster analysis on resting-state fMRI
A timely and effective evaluation of the suicidal ideation bears practical meaning, particularly
for the depressive who tend to disguise the real suicide intent and without obvious …
for the depressive who tend to disguise the real suicide intent and without obvious …
Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial
In designing co-clinical cancer studies, preclinical imaging brings unique challenges that
emphasize the gap between man and mouse. Our group is developing quantitative imaging …
emphasize the gap between man and mouse. Our group is developing quantitative imaging …
Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals
M Hoogenboom, MJ van Amerongen… - Journal of therapeutic …, 2015 - Springer
Background Thermal and mechanical high intensity focused ultrasound (HIFU) ablation
techniques are in development for non-invasive treatment of cancer. However, knowledge of …
techniques are in development for non-invasive treatment of cancer. However, knowledge of …
A novel unsupervised segmentation approach quantifies tumor tissue populations using multiparametric MRI: first results with histological validation
Purpose We aimed to precisely estimate intra-tumoral heterogeneity using spatially
regularized spectral clustering (SRSC) on multiparametric MRI data and compare the …
regularized spectral clustering (SRSC) on multiparametric MRI data and compare the …
Fluorine MR imaging monitoring of tumor inflammation after high-intensity focused ultrasound ablation
Purpose To investigate whether high-intensity focused ultrasound (HIFU)-induced
macrophage infiltration could be longitudinally monitored with fluorine 19 (19F) magnetic …
macrophage infiltration could be longitudinally monitored with fluorine 19 (19F) magnetic …