Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …

Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1)
blockade in cancer patients, but the mechanisms underlying their immunosuppressive …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

Autoimmune diseases are a result of the immune system being misdirected toward its host
and have major and increasing unmet clinical needs. In general, present therapies are …

Targeting cytokines in inflammatory bowel disease (IBD) is a useful clinical approach.
Potential therapies for IBD include regulatory T cell transfer to restore cytokine balance …

Crohn's disease can affect any part of the gastrointestinal tract; however, current European
and national guidelines worldwide do not differentiate between small-intestinal and colonic …

Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

In vitro models of autoimmunity are constrained by an inability to culture affected epithelium
alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is …

Immune cell trafficking is a complex and tightly regulated process that is indispensable for
the body's fight against pathogens. However, it is also increasingly acknowledged that …