Improved symptom profiles and minimal inflammation in IBS-D patients undergoing a long-term low-FODMAP diet: a lipidomic perspective

A Orlando, V Tutino, M Notarnicola, G Riezzo… - Nutrients, 2020 - mdpi.com
Given the link between the minimal inflammation underlying irritable bowel syndrome (IBS)
and dietary treatments, considerable attention has focused on diets low in fermentable …

[HTML][HTML] Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome

DR Liu, XJ Xu, SK Yao - World journal of gastroenterology, 2018 - ncbi.nlm.nih.gov
AIM To measure the leptin levels in patients with diarrhea-predominant irritable bowel
syndrome (IBS-D) and analyze the relationship of leptin with clinical features, visceral …

A putative anti‐inflammatory role for TRPM8 in irritable bowel syndrome—An exploratory study

M Peiris, ZZRM Weerts, R Aktar… - …, 2021 - Wiley Online Library
Background Chronic and recurring pain is a characteristic symptom in irritable bowel
syndrome (IBS). Altered signaling between immune cells and sensory neurons within the gut …

The ketogenic diet reduces the harmful effects of stress on gut mitochondrial biogenesis in a rat model of irritable bowel syndrome

G Chimienti, A Orlando, AMS Lezza… - International journal of …, 2021 - mdpi.com
Functional alterations in irritable bowel syndrome have been associated with defects in
bioenergetics and the mitochondrial network. Effects of high fat, adequate-protein, low …

Drug discovery approaches to irritable bowel syndrome

PJ Hornby - Expert opinion on drug discovery, 2015 - Taylor & Francis
Introduction: Irritable bowel syndrome (IBS) is defined by symptoms of abdominal pain and
altered bowel habits without detectable organic disease. Antidepressants and serotonin …

Variation and interdependencies of human milk macronutrients, fatty acids, adiponectin, insulin, and IGF-II in the European PreventCD Cohort

M Grunewald, C Hellmuth, FF Kirchberg, ML Mearin… - Nutrients, 2019 - mdpi.com
Human milk composition is variable. The identification of influencing factors and
interdependencies of components may help to understand the physiology of lactation. In this …

Adipose Tissue‐Derived Biomarkers of Intestinal Barrier Functions for the Characterization of Diarrhoea‐Predominant IBS

F Russo, G Chimienti, G Riezzo, M Linsalata… - Disease …, 2018 - Wiley Online Library
Background. Alterations of the small‐intestinal permeability (s‐IP) might play an essential
role in a subgroup of diarrhoea‐predominant IBS (D‐IBS) patients. Goals.(a) To analyse in D …

Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity

L Prospero, G Riezzo, M Linsalata, A Orlando… - BMC …, 2021 - Springer
Background Irritable bowel syndrome (IBS) is characterised by gastrointestinal (GI) and
psychological symptoms (eg, depression, anxiety, and somatization). Depression and …

Effect of a 12-Week Walking Program Monitored by Global Physical Capacity Score (GPCS) on Circulating Cell-Free mtDNA and DNase Activity in Patients with …

G Chimienti, F Russo, A Bianco, F Maqoud… - International Journal of …, 2024 - mdpi.com
Irritable bowel syndrome (IBS) involves low-grade mucosal inflammation. Among the various
approaches capable of managing the symptoms, physical activity is still under investigation …

Lipidomic analysis of fatty acids in erythrocytes of coeliac patients before and after a gluten-free diet intervention: a comparison with healthy subjects

G Riezzo, C Ferreri, A Orlando, M Martulli… - British journal of …, 2014 - cambridge.org
Coeliac disease (CD) patients may exhibit a pro-inflammatory profile and fatty acids (FA) can
influence inflammation through a variety of cellular pathways in them. The aims of the …