Despite a great deal of attention over many years, the structural and functional roles of the
linker histone H1 remain enigmatic. The earlier concepts of H1 as a general transcriptional …

H1 and related linker histones are important both for maintenance of higher-order chromatin
structure and for the regulation of gene expression. The biology of the linker histones is …

Disordered proteins play an essential role in a wide variety of biological processes, and are
often posttranslationally modified. One such protein is histone H1; its highly disordered C …

The compaction level of arrays of nucleosomes may be understood in terms of the balance
between the self-repulsion of DNA (principally linker DNA) and countering factors including …

Linker histones bind to the nucleosome and regulate the structure of chromatin and gene
expression. Despite more than three decades of effort, the structural basis of nucleosome …

Linker histones associate with nucleosomes to promote the formation of higher-order
chromatin structure, but the underlying molecular details are unclear. We investigated the …

Chromatin structure plays a fundamental role in the regulation of nuclear processes such as
DNA transcription, replication, recombination, and repair. Despite considerable efforts …

The nucleus of eukaryotes is organized into functional compartments, the two most
prominent being heterochromatin and nucleoli. These structures are highly enriched in DNA …

Single chicken erythrocyte chromatin fibers were stretched and released at room
temperature with force-measuring laser tweezers. In low ionic strength, the stretch-release …

To understand how nuclear processes involving DNA are regulated, knowledge of the
determinants of chromatin condensation is required. From recent structural studies it has …