TDP-43 pathology: from noxious assembly to therapeutic removal
Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …
Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
Y Tamaki, M Urushitani - International journal of molecular sciences, 2022 - mdpi.com
TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal
cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated …
cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated …
[HTML][HTML] The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via …
ER Gallagher, ELF Holzbaur - Cell reports, 2023 - cell.com
In response to lysosomal damage, cells engage several quality-control mechanisms,
including the selective isolation and degradation of damaged lysosomes by lysophagy …
including the selective isolation and degradation of damaged lysosomes by lysophagy …
Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates
Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis
The methyltransferase complex (MTC) deposits N 6-adenosine (m6A) onto RNA, whereas
the microprocessor produces microRNA. Whether and how these two distinct complexes …
the microprocessor produces microRNA. Whether and how these two distinct complexes …
A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP‐43 and modulates its phase behavior
Abstract TAR DNA‐binding protein 43 (TDP‐43) is a multidomain protein involved in the
regulation of RNA metabolism, and its aggregates have been observed in …
regulation of RNA metabolism, and its aggregates have been observed in …
Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation
J Liu, C Zhao, X Xiao, A Li, Y Liu, J Zhao, L Fan… - Nature …, 2023 - nature.com
Mechanotransduction in endothelial cells is critical to maintain vascular homeostasis and
can contribute to disease development, yet the molecules responsible for sensing flow …
can contribute to disease development, yet the molecules responsible for sensing flow …
Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
Metamorphism in TDP-43 prion-like domain determines chaperone recognition
J Carrasco, R Antón, A Valbuena… - Nature …, 2023 - nature.com
The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like
domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon …
domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon …
Molecular chaperones' potential against defective proteostasis of amyotrophic lateral sclerosis
S Kinger, AR Dubey, P Kumar, YA Jagtap… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neuronal degenerative condition identified via a
build-up of mutant aberrantly folded proteins. The native folding of polypeptides is mediated …
build-up of mutant aberrantly folded proteins. The native folding of polypeptides is mediated …