Stroke is the second leading cause of mortality and the major cause of adult physical
disability worldwide. The currently available treatment to recanalize the blood flow in acute …

Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Barriers between circulation and the central nervous system (CNS) play a key role in the
development and modulation of CNS immune responses. Structural variations in the …

Microglia sustain normal brain functions continuously monitoring cerebral parenchyma to
detect neuronal activities and alteration of homeostatic processes. The metabolic pathways …

The immune response after stroke is known to play a major role in ischemic brain
pathobiology. The inflammatory signals released by immune mediators activated by brain …

Neuroinflammation is initiated in response to ischemic stroke, generally with the hallmarks of
microglial activation and collateral brain injury contributed by robust inflammatory effects …

Review on the time-dependent recruitment of inflammatory cells and unanswered questions
regarding inflammatory cells in the pathophysiology of ischemic stroke. Inflammation plays …

Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

Microglia are the resident immune cells of the brain and react quickly to changes in their
environment with transcriptional regulation and morphological changes. Brain tissue injury …