Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

The onset of clinical assisted reproduction, a quarter of a century ago, required the isolation
of motile spermatozoa. As the indication of assisted reproduction shifted from mere …

Nearly half of all pregnancies are unintended; thus, existing family planning options are
inadequate. For men, the only choices are condoms and vasectomy, and most current efforts …

The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility
and fertilization via HCO3−-stimulated cAMP synthesis. A complex network of signaling …

Background In sea urchins, spermatozoan motility is altered by chemotactic peptides, giving
rise to the assumption that mammalian eggs also emit chemotactic agents that guide …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Testicular spermatozoa acquire fertility only after 1 or 2 weeks of transit through the
epididymis. At the end of this several meters long epididymal tubule, the male gamete is …

BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …

The genetic bases and molecular mechanisms involved in the assembly and function of the
flagellum components as well as in the regulation of the flagellar movement are not fully …

Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in
the female reproductive tract and by triggering key sperm physiological responses required …