Collagen hydrogels are among​ the most well-studied platforms for drug delivery and in situ
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …

While tissue engineering holds significant potential to address current limitations in
reconstructive surgery of the head and neck, few constructs have made their way into routine …

The laryngotracheal cartilage is a cardinal framework for the maintenance of the airway for
breathing, which occasionally requires reconstruction. Because hyaline cartilage has a poor …

Tissue engineering is a relatively recent research area aimed at developing artificial tissues
that can restore, maintain, or even improve the anatomical and/or functional integrity of …

Objective/Hypothesis There are currently no treatments available that restore dynamic
laryngeal function after hemilaryngectomy. We have shown that dynamic function can be …

Aim: To evaluate dermal regeneration scaffolds custom-fabricated from fibril-forming
oligomeric collagen where the total content and spatial gradient of collagen fibrils was …

The larynx is responsible for breathing, producing sound, and protecting the trachea against
food aspiration through the cough reflex. Nowadays, scaffolding surgery has made it easier …

We have developed a cell-based outer vocal fold replacement (COVR) as a potential
therapy to improve voice quality after vocal fold (VF) injury, radiation, or tumor resection. The …

Type I collagen is the predominant protein in the body and the extracellular matrix, where it
gives rise to the vast diversity of tissue form and function. Within the extracellular matrix, this …

Objective Tissue engineering of the larynx requires a complex, multiple tissue layer design.
Additionally, spontaneous reinnervation of the larynx after recurrent laryngeal nerve (RLN) …