The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Cell division and cell death are fundamental processes governing growth and development
across the tree of life. This relationship represents an evolutionary link between cell cycle …

The cell cycle involves a network of proteins that modulate the sequence and timing of
proliferation events. Unregulated proliferation is the most fundamental hallmark of cancer; …

The proto-oncogene c-Myc regulates multiple biological processes mainly through
selectively activating gene expression. However, the mechanisms underlying c-Myc …

Background: Over the past four decades, outcomes for osteosarcoma patients have
plateaued as there have been few emerging therapies showing clinical results. Thus, the …

Cell cycle gene expression occurs in two waves. The G1/S genes encode factors required
for DNA synthesis and the G2/M genes contribute to mitosis. The Retinoblastoma protein …

Alternative polyadenylation (APA) yields transcripts differing in their 3′-end, and its
regulation is altered in cancer, including prostate cancer. Here we have uncovered a …