Research in the field of ischemia-reperfusion injury continues to be plagued by the inability
to translate research findings to clinically useful therapies. This may in part relate to the …

Tacrolimus (FK 506) is a macrolide immunosuppressant which possesses similar but more
potent immunosuppressant properties compared with cyclosporin, inhibiting cell-mediated …

The use of oral and intravenous cyclosporin represents a significant advance in the therapy
of refractory inflammatory bowel diseases (IBD). However, oral administration of cyclosporin …

Administration of a hapten together with a barrier breaker, such as ethanol, into the colon of
a rat results in extensive mucosal injury and inflammation that bears some similarity to the …

Publisher Summary The powerful immunosuppressive activity of ciclosporin (CS), which is
apparently restricted at the cellular level of certain T lymphocytes, is recognized as a …

Recirculation following 2 h of focal ischemia due to transient middle cerebral artery (MCA)
occlusion has previously been found to be accompanied by an initial, partial recovery of the …

Beginning 15 min after induction of intracerebral hemorrhage (ICH) by intrastriatal
administration of collagenase, rats were treated intramuscularly with FK-506 (3 mg/kg) or …

The gastrointestinal tract can be deranged by ailments including sepsis, trauma and
haemorrhage. Ischaemic injury provokes a common constellation of microscopic and …

The overall objective of this study was to determine whether T lymphocytes can modulate
the increased neutrophil adherence and upregulation of endothelial cell adhesion …

The expression of the neutrophil chemokine macrophage inflammatory protein-2 (MIP-
2/CXCL2) and the monocyte chemokine monocyte chemotactic protein-1 (MCP-1/CCL2) …